Not known Factual Statements About sodium pentobarbital
Not known Factual Statements About sodium pentobarbital
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pentobarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of CYP3A4 inducers might minimize sufentanil ranges and efficacy, quite possibly precipitating withdrawal syndrome in sufferers who've created physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers may perhaps enhance sufentanil plasma concentration.
Contraindicated (1)pentobarbital will minimize the level or effect of doravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will lessen the level or effect of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Effect of coadministering a robust CYP3A4 inducer with fedratinib has not been researched.
pentobarbital will minimize the extent or effect of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. For people with ED, watch reaction diligently on account of likely for lowered effectiveness.
pentobarbital will minimize the extent or effect of ramelteon by affecting here hepatic enzyme CYP2C9/ten metabolism. Slight/Importance Unfamiliar.
pentobarbital will lower the level or effect of conjugated estrogens, vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will lower the extent or effect of almotriptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
lasmiditan, pentobarbital. Both improves effects from the other by sedation. Use Warning/Keep an eye on. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol haven't been evaluated in clinical studies. Lasmiditan might cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
pentobarbital will lessen the extent or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Griseofulvin: Phenobarbital seems to interfere with the absorption of orally administered griseofulvin, Consequently lowering its blood stage.
pentobarbital increases effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor. Coadministration of ifosfamide with CYP2B6 inducers may well enhance metabolism of ifosfamide to its metabolite. Check for elevated effects/toxicities if put together with CYP2B6 inducers.
pentobarbital will reduce the level or effect of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Loss of, or lowered response to tofacitinib could come about when coadministered with potent CYP3A4 inducers
pentobarbital will lessen the level or effect of fruquintinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration with average CYP3A4 inducers is unavoidable, continue on to administer fruquintinib at encouraged dosage.